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identifying potential drug leads & small molecule tools

chemical genetics

Burns, A.R.*, Luciani, G.M.*, Musso, G., Bagg, R., Yeo, M., Zhang, Y., Rajendran, L., Glavin, J., Hunter, R., Redman, E., Stasiuk, S., Schertzberg, M., McQuibban, G.A., Caffrey, C.R., Cutler, S., R., Tyers, M., Giaever, G., Nislow, C., Fraser, A.G., MacRae, C. A., Gilleard, J. and Roy, P.J.§. 2015. Caenorhabditis elegans is a useful model for Anthelmintic Discovery. Nature Communications. 6:7485 | DOI: 10.1038/ncomms8485

Luciani, G.M., Magomedova, L., Puckrin, R., Urbanus, M., L., Wallace, I.M., Giaever, G., Nislow, C., Cummins, C.L. , and Roy, P.J. 2011. Dafadine Inhibits DAF-9 to Promote Dauer-Formation and Longevity of Caenorhabditis elegans. Nature Chemical Biology 7, 891-893. doi: 10.1038/nchembio.698. PMID: 22057127
 

Wallace, I.M., Urbanus, M.L., Luciani, G.M., Arora, K., Heisler, L.E., Lee, W., Proctor, M., Burns, A.R., St. Onge, R.P., Roy, P.J., Bader, G.D., Nislow, C., and Giaever, G. 2011. Compound prioritization methods increase rates of chemical probe discovery in model organisms. Chem Biol. 18, p1273-1283. PMID:22035796
 

Burns, A.R., Wallace, I.M., Wildenhain, J., Tyers, M., Giaever, G., Bader, G., Nislow, C., Cutler, S.R., and Roy, P.J. 2010. A Predictive Model for Drug Bioaccumulation and Bioactivity in Caenorhabditis elegans. Nature Chemical Biology, 6, p549-557 (DOI:10.1038/nchembio.380).
 

Kwok, T.C.Y., Hui, K., Kostelecki, W., Selman, G., Ricker, N., Feng, Z.P., and Roy, P.J. 2008. A Screen for Dihydropyridine (DHP)-Resistant Worms Reveals a Mechanism for DHP-Blockage of Mammalian Calcium Channels. PLoS Genetics 4(5):e1000067 doi:10.1371/journal.pgen.1000067 full text
 

Hui, K., Kwok, T.C.Y., Kostelecki, W., Leen, J., Roy, P.J.§, and Feng, Z.P. 2009. Differential sensitivities of CaV1.2 IIS5-S6 mutants to 1,4-dihydropyridine analogs. European Journal of Pharmacology, 602, p255-261. PMID: 19068212
 

Arnoldo, A., Curak, J., Kittanakom, S., Chevelev, I., Lee, V.T., Sahebol-Amri, M., Koscik, B., Ljuma, L., Roy, P.J., Bedalov, A., Giaever, G., Nislow, C., Merrill, R. A., Lory, S., and Stagljar, I. 2008. Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen. PLoS Genetics, 4(2): e1000005. doi:10.1371/journal.pgen.1000005 full text
 

Burns, A.R., Kwok, T.C.Y., Howard, A., Houston, E., Johanson, K., Chan, A., Cutler, S.R., McCourt, P., Roy, P.J. 2006. High-throughput Screening of Small Molecules for Bioactivity and Target Identification in Caenorhabditis elegans. Nature Protocols. 1, 1906-1914. PDF
 

Kwok, T., Ricker, N., Fraser, R., Chan, A., Burns, A., Stanley, E.F., McCourt, P., Cutler, S., and Roy, P.J. 2006. A Small Molecule Screen in C. elegans Yields a New Calcium Channel Antagonist. Nature. 441(7089):91-5. PMID: 1667297