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the Roy lab is working towards discovering new drug-like
compounds that could be used
to treat human disease

we are developing C. elegans as a
model for human diseases related to
neurodegeneration, myopathies,
vascular malfunctions, and
psychological disorders

 we are also using the non-parasitic
C. elegans as a model of parasitic nematodes, which infect over
one third of humans

we use these models to identify drug-like compounds that ameliorate the defects, and partner with other labs to test our compounds in corresponding disease models in fish and mice

more detail

the guided migration of cells and axons is essential for the proper development of all animals, including humans

the Roy Lab identifies new components
required for the guided migration of
cells and axons by studying membrane
extensions from both neurons and muscles
of the C. elegans nematode

through the genetic analyses of these
processes, the Roy lab has discovered a
novel guidance cue called MADD-4 that
signals through an UNC-40/DCC-EVA-1
receptor complex

the Roy lab has also discovered a novel
adaptor protein of the UNC-40/DCC
receptor called MADD-2, which is also
conserved with humans

more detail